This paper analyzes the current situation of hospital informatization, and puts forward a new solution to realize the integration of hospital information system to make up the defects of the traditional integration scheme in the current hospital informatization construction. Furthermore, it introduces the software architecture and development planning, as well as expounds the operation process of Internet hospital, including website diagnosis and treatment and Medical Union service system. Each independent medical information subsystem is closely linked through the hospital information integration platform. On the base of the open architecture, the integration platform has strong scalability and supports the connection of customized adapters and the application of complex heterogeneous systems, so as to realize the data sharing and information collaboration among various hospital systems.