The last couple of years has constantly shown that ICT can and is used to destabilize and undermine societies and countries using hybrid-based tools and methodologies. Russia’s hybrid war against Ukraine is a clear example of the strength that the hybrid threats pose. Due to its position and previous war conflicts, countries from South-East Europe (SEE) are constantly targeted under the threat of hybrid threats. This chapter gives an overview of the nontechnical measures that can be applied to increase the resilience in the SEE region, and an overview of the AI (Artificial intelligence) based tools and techniques that can be used to generate and combat hybrid threats, especially the disinformation and fake news.