On March 11, 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the highly infectious virus that causes coronavirus disease (COVID-19), was characterized by the World Health Organization (WHO) as a global pandemic [1,2]. Due to its highly contagious nature, COVID-19 has catalyzed the introduction of non-pharmaceutical interventions such as social distancing and quarantine measures [6]. Thus, the pandemic has shifted society to become reliant on healthcare technologies. The objective of this scoping review is to establish what health informatics interventions have been applied, validated and tested globally during the COVID-19 pandemic. The findings demonstrated a range of 12 types of health informatics interventions with various global applications and use. As evidenced by the intervention heterogeneity, the necessity to adopt a global cohesive strategy to improve human safety through the utilization of smart, efficient, and communicable technologies is vital.