This is a study protocol to evaluate the Impact of digital games on learning medical terminology of paramedical students. An unblinded randomized controlled trial (RCT) 2-arm, with 1:1 allocation ratio was randomized by 60 students at the faculty of paramedical science at Mashhad University of Medical Science(MUMS), Iran, who had their medical terminology course at the time of this study, would enter the study. To evaluate the game, Participants in both groups attended typical teaching in traditional instructional activities for two months; however, the intervention group played the smartphone-based digital game during the course. The knowledge level of students in the control and intervention group were measured before and immediately after the intervention using the pre-designed questionnaire. This study was approved by the ethical committee of MUMS (approval number IR.MUMS.REC.1400.336).