Chemical, analytical and biological laboratories use a variety of different solvents and gases. Many of these compounds are harmful or even toxic to laboratory personnel. Permanent monitoring of the air quality is therefore of great importance regarding the greatest possible occupational safety and the detection of dangerous situations in the work process. An increasing need exists for the development and application of small and portable sensor solutions that enable personal monitoring and that can be flexibly adapted to different environments and situations. Different sensor principles are available for the detection of gases and solvent vapors, which differ in terms of their selectivity and sensitivity. Besides simple sensing elements, integrated sensors and smart sensors are increasingly available, which, depending on their scope of functions, require a distinct effort in integration. This chapter gives an overview of available sensors and their integration options, and describes ready-to-use sensor systems for personal monitoring in life science laboratories.