Digital transformation toward optimized production process planning, highlights new challenges for assembly process planning departments as we move toward fully virtual engineering processes. ESI Software Germany GmbH (ESI) wants to introduce an important project outcome generated by the MOSIM (Modular Simulation of Human Motions, www.mosim.eu) framework – an open framework for efficient, interactive simulation and analysis of realistic human motion of manual assembly-worker sequences for industrial applications. The ESI – IC.IDO solution is one of the proposed industry solutions aiming to re-use the project outcome to extend existing IC.IDO process validation capabilities and enhance human-centric assembly environment validations completed in entirely virtual try-outs. Currently, the impact of assembly process plans on the people, who produce, use, and maintain a proposed new product, is often left unquantified until late in the product lifecycle. In some cases, identification of issues comes too late to mitigate through product design change or improved assembly methods for the shop floor. The goal of MOSIM is to increase comprehension of, and provide capability to shift, manufacturing engineering paradigms through the integrated evaluation of products in processes with the people who build, use, and maintain those products throughout their lifecycle. There are no solutions on the market yet, which comprehensively address human-centric engineering factors during assembly process planning that includes on-board realistic human simulation capabilities. ESI intends to use the MOSIM project results to improve manual, human-performed, manufacturing assembly procedure validations and generate dynamic simulations of human-centric motion in production environments. This will lead to a major reduction of time and effort needed to conduct shopfloor worker assembly simulations compared to current industrial practice – compared to approaches using digital mock-up (DMU) solutions for worker simulation studies. Identifying ergonomic opportunities during the assembly process to improve worker productivity, safety, and training. MOSIM has enormous potential to influence numerous stages of production.