This study constructs a new mixed reality MR holographic teaching application course, summarizes its more than 5 years’ research and practical experience in the digital media direction of Wenzhou Business School, and discusses the universality and shortcomings of mixed reality MR holographic teaching to digital media majors and other domestic university digital media majors combined with the needs of the society and the characteristics of the digital media direction of visual communication design major. The practical exploration of this teaching model and method not only improves the construction effectiveness and talent training quality of the mixed reality MR holographic teaching course in the digital media major direction of Wenzhou Business School, but also plays a leading and exemplary role in the construction and demonstration of related professional courses in other colleges and universities.