By introducing the Vehicle Routing, Scheduling & Dispatching Problem for Multiples Depot (VRSDP/MD) and the description of formalization, it is helpful to offer a solution to solve the complex situation in practical transportation problem. In order to decrease the influence of the problem, A computing model embodying Hierarchical Multiplex Structure to take shape with an object-oriented multiple paradigms (HIMS+ model) are put forward as a proposal. And HIMS+ is divided into three layers: the first layer is the system cost adjusting area, the second layer is formation area for the system state, and that, the third layer is decision-making area for the system optimization. Two methods of meta-heuristic and fuzzy inference are proposed as an optimality calculation for HIMS+ architecture. There are two types of 24 tank lorries in the metropolis of Japan (Tokyo area), where two types of experiments are scheduled for 3-day of actual order data. Experiments results show that the HIMS+ model increase acceleration by 10 percent and decreases fast by 75 percent compared to what experts predict. The HIMS+ model has become a very reliable computing architecture for the multi objective and multi constraint optimization to real world transportation problems.