The present study is conducted to determine the status of e-learning, student satisfaction and the relationship between these two variables in Zahedan University of Medical Sciences (ZAUMS). According to a descriptive study, there was just a significant difference between the mean score of e-Learning experience and student satisfaction, and a positive correlation between the education level and student satisfaction. Also, there was a positive correlation between all variables of e-learning and student satisfaction The findings showed that the more capable learners were outcome of better educational content, stronger e-learning infrastructure, better support and assessment of e-learning quality, which, in turn, resulted in the greater the students’ satisfaction. As a result, the experiences from the evaluation of e-learning in the Covid-19 pandemic period may be regarded a good guide in improving the course during the Covid-19 pandemic, and also it can be considered a key factor in providing educations in the post-Covid-19 period.