Semantic space creation and computing are essentially significant to realize semantic interpretations of situations and symptoms in human-health. We have presented a semantic space creation and computing method for domain-specific research areas. This method realizes semantic space creation with domain-oriented knowledge and databases. This paper presents a semantic space creation and computing method for “Human-Health Database” with the implementation process for “Human-Health-Analytical Semantic Computing”. This paper also presents a new knowledge base creation method for personal health data for preventive care and potential risk inspection with global and geographical mapping and visualization in 5-Dimensional World Map System. This method focuses on the analysis of personal health and potential-risk inspection and realizes a set of semantic computing functions for semantic interpretations of situations and symptoms in human-health. This method is applied to “Human-Health-Analytical Semantic Computing” to realize world-wide evaluation for (1) multi-parameterized personal health data, such as various biomarkers, clinical physical parameters, lifestyle parameters, other clinical/physiological or human health factors, etc., for health monitoring, and (2) time-series multi-parameterized health data in the national/regional level for global analysis of potential cause of disease. This Human-Health-Analytical Semantic Computing method realizes a new multidimensional data analysis and knowledge sharing for a global-level health monitoring and disease analysis. The computational results are able to be visualized in the time-series difference of the values in each place, the difference between the values of multiple places in a focused area, and the time-series differences between the values of multiple places to detect and predict a potential-risk of diseases.