Alzheimer’s disease (AD) is a degenerative disease of the nervous system. Mild cognitive impairment (MCI) is a condition between brain aging and dementia. The prediction will be divided into stable sMCI and progressive pMCI as a binary task. Structural magnetic resonance imaging (sMRI) can describe structural changes in the brain and provide a diagnostic method for the detection and early prevention of Alzheimer’s disease. In this paper, an automatic disease prediction scheme based on MRI was designed. A dense convolutional network was used as the basic model. By adding a channel attention mechanism to the model, significant feature information in MRI images was extracted, and the unimportant features were ignored or suppressed. The proposed framework is compared with the most advanced methods, and better results are obtained.