Lyme disease appears by various means one of the causes is infection from a bite of a black-legged tick which leads to the formation of a rash called Erythema Migrans (EM). This Lyme disease is the direct root of skin cancer and the primary phase is known as Basal Cell Carcinoma (BCC). Skin cancer causes pathological situations it integument the body’s surfaces, including skin, hair, nails, and associated glands. Identifying EM and BCC in biomedical representation is a common platform known as biopsies and many works are done in the traditional methodology. But early detection of EM and BCC in the field of medical imaging using computer-aided diagnosis provides more accuracy and rapidity. This survey is classified under two categories; the first is EM detection and the second is the segmentation of BCC. The circumstances of this review are under the base of different algorithms, various methods used by the non-medicals appliance are discussed and compared by the several measures taken by increasing the parameters to improve the accuracy levels.