The COVID-19 pandemic has quickly and radically transformed health systems worldwide. The challenges are imposed by the need for social distance, remote management of less severe cases, and the constant need for updating health care professionals and the population with reliable information. We aim to describe the experiences and developments of a Brazilian telehealth public service during the pandemic. Numerous tools have been developed and made available, to be used in an integrated manner, by both health professionals and the general public. Those included a chatbot for guidance, a teleconsultation platform combined with a telemonitoring system, a teleconsulting service, and a tele-education program. The TNMG services appear to be efficient and robust during the health crisis of COVID-19, through different tools and methodologies focused on both professionals and users of the health systems.