Along with the proposal of the Belt and Road initiative, the Eurasian railway lines with China and Russia as the center are entering a new era of strategic coordination. Thus, carrying out digital location design with modern mapping information technology has become a necessary means for improving railway locating efficiency and quality. Employing the GIS-based large 3D strip terrain modeling approach and its application, the present study takes consideration in factors such as slope, relief, geological disasters, and locating-influencing surface features so as to construct the most economically efficient routes and form the optimal GIS-based plans and decisions. Specific railway lines undergo BIM locating design with an integrated use of Civil 3D and Infraworks360 software. Line modeling and earthwork calculation are conducted in the Civil 3D-based terrain curvature. Moreover, line model is imported into Infraworks360 to achieve a 3D roaming demonstration. A 3D visualized implementation of railway location design is made possible using GIS+BIM approach that improves locating efficiency and design quality.