Increasing manufacturing efficiency has been a constant challenge since the First Industrial Revolution. What started as mechanization and turned into electricity-driven operations has experienced the power of digitalization. Currently, the manufacturing industry is experiencing an exponential increase in data availability, but it is essential to deal with the complexity and dynamics involved to improve manufacturing indicators. The aim of this study is to identify and allow an understanding of the unfilled gaps and the opportunities regarding production scheduling using machine learning and data science processes. In order to accomplish these goals, the current study was based on the Knowledge Development Process – Constructivist (ProKnow-C) methodology. Firstly, selecting 30 articles from 3608 published articles across five databases between 2015 and 2019 created a bibliographic portfolio. Secondly, a bibliometric analysis, which generated comparative charts of the journals’ relevance regarding its impact factor, scientific recognition of the articles, publishing year, highlighted authors and keywords was carried out. Thirdly, the selected articles were read thoroughly through a systemic analysis in order to identify research problems, proposed solutions, and unfilled gaps. Then, research opportunities identified were: (i) Big data and associated analytics; (ii) Collaboration between different disciplines; (iii) Solution Customization; and (iv) Digital twin development.