Compared with ordinary large-scale structural parts, super-large aircraft aluminum alloy integral frame parts have the characteristics of large size, high ribs and thin-walled, which lead to the difficulty of deformation control and dimensional accuracy assurance in the machining process, and the problems of spring knife and broach are easy to occur. In this paper, the research on super-large aluminum alloy integral frame parts is carried out, and a set of methods with part deformation control and coordinate drift error control are proposed, and the processing programming strategy is further optimized. This method has been successfully applied to a super-large aircraft aluminum alloy integral frame part, which greatly reduces the deformation of parts, improves the processing stability, and improves the processing efficiency by about 30%.