The interdisciplinary development of smart factories and cyber-physical systems CPS shows the weaknesses of classical development methods. For example, the communication of the interdisciplinary participants in the development process of CPS is difficult due to a lack of cross-domain language comprehension. At the same time, the functional complexity of the systems to be developed increases and they act operationally as independent CPSs. And it is not only the product that needs to be developed, but also the manufacturing processes are complex. The use of graph-based design languages offers a technical solution to these challenges. The UML-based structures offer a cross-domain language understanding for all those involved in the interdisciplinary development process. Simulations are required for the rapid and successful development of new products. Depending on the functional scope, graphical simulations of the production equipment are used to simulate the manufacturing processes as a digital factory or a virtual commissioning simulation. Due to the high number of functional changes during the development process, it makes sense to automatically generate the simulation modelling as digital twins of the products or means of production from the graph-based design languages. The paper describes how digital twins are automatically generated using AutomationML according to the Reference Architecture Model Industry 4.0 (RAMI 4.0) or the Industrial Internet Reference Architecture (IIRA).