Temporomandibular disorder (TMD) is a prevalent dental disease in common with dental caries and periodontitis. The major symptoms of TMD are masticatory muscle pain, temporomandibular joint (TMJ) pain and impairment of jaw movement due to the pain and pathologic derangement of TMJs. However, there are few studies using TMD patient-specific motion data to drive the musculoskeletal model that can elucidate kinematic and biomechanical characteristics of the patient. The purpose of this study is to develop the workflow of musculoskeletal modeling of the mandible with jaw motion data obtained from a TMD patient. This involves the establishment of patient-specific boundary conditions representing the characteristics of the TMJ. The jaw motion of a TMD patient was recorded and used as an input for driving the model.