Digital Human Modeling Systems (DHM’s) benefit from detailed up to date anthropometric data. Whereas the clothing industry focuses on anthropometric measures according to ISO-18825-2, ergonomic- and safety-related measures are defined in ISO 7250-1. For the current research project, body scan data was collected as part of an epidemiological study (Study of Health in Pomerania, SHIP). ISO 20685-1 recommends a validation study for the comparison of manual vs. 3D body scan data from at least 40 persons, if the data should be considered in anthropometric databases. The current study evaluated data of 44 participants. The scans and the manual measurements for each participant were taken successively at the same day. The definition of anatomical landmarks differed for some parameters between the ISO 7250-1 standard and the standard operating procedures (SOP’s) of the SHIP study. As it was not possible to change the methods of the SHIP study, the authors performed a relative offset calculation. With few exceptions, the validation measures exceeded the maximum error allowances from ISO 20685-1:2018. The paper discusses possible root causes of the evaluated differences.