This chapter explores how southern African states and other stakeholders are responding to maritime insecurity challenges by focusing on responses to insecurity in northern Mozambique. The maritime and littoral environment in the northern Mozambique Channel and onshore in the Cabo Delgado province represents a unique nexus of African-driven counter-piracy, counter-terrorism and counter-narcotic initiatives. It arguably represents a future fulcrum or pivotal area, not simply for Mozambique, but numerous actors around the world. Yet it remains an under-studied area. This chapter begins by outlining why the northern Mozambique Channel has become so significant an area over the past decade. It looks at the development of a multilateral and regional responses, as primarily perceived and driven by South Africa, and how stakeholders have struggled to overcome some key hurdles in the enhancing of maritime security.