This mixed-method research aimed to evaluate in need assessments and develop an intervention model for quality improvement information system-QIIS for surveillance and monitoring Patient safety and Personals safety in Kalasin Hospital, Thailand. The process was divided into 3 phases, 1) Studies on needs assessments of patients and hospital staff-2P, 2) Develop the program and assessment 3) Program implementation and evaluation. The 245 participants were participated during October 2019 – Februarys 2020. A questionnaire and semi-structure interview by content analysis were applied to investigate on needs assessments and intervention evaluation were using checklist for observation. The results revealed that information alert from supportive technology especially in real-time were sophisticated improving and significantly increasing with the positively and satisfaction levels of the staff increasingly particularly in pre and post observation (p-value <0.05). The key success of QIIS was comprised as suddenly response and information alert system, for this reason their staff could be immediately responsive to problems as much as they affords.