E-learning enables students to participate in online courses across universities. As a part of the HiGHmed joint teaching and training program, we developed an e-learning module entitled Health Enabling Technologies and Data based on the Gilly Salmon 5 stage model didactic concept. This course was implemented at a German Technical University in the winter semester 2019/20 and evaluated by the students after completion. Student evaluation indicates good teaching presence but improvable social presence. From the perspective of the lecturers, we have learned that interactivity should be enhanced to improve the students’ engagement, and incentives shall be established to foster students’ active participation. Therefore, we will revise the course for the next term by (i) web conferences, (ii) assessment of interactivity, and (iii) clear “take-home” messages.