The increased prevalence and frequency of infectious diseases are alarming with respect to the disproportionate fatalities across different regions, socio-economic conditions, and demographic groups. Combining pathological data, socio-environmental data, and extracted knowledge from white papers, we proposed a Globally Localized Epidemic Knowledge base (GLEK) that can be utilized for efficient and optimal epidemic surveillance. GLEK merges social, environmental, pathological, and governmental intervention data to provide efficient advice for epidemic control and intervention. Heuristically utilizing multi-locus data sources, GLEK can identify the best tailored intervention.