Artificial Intelligence – (AI) is the intelligence proved by machines, robots and is the contrast of the natural intelligence, which belongs to humans and animals. AI is the intelligence that mankind created. When creating an artificial intelligence system, one of the most difficult problems is the computer simulation of certain actions: to create sounds and to judge, to draw conclusions on the basis of mere perceptions of certain situations. One of the main characteristics of Artificial Intelligence is their capacity to learn with or without help from the outside, with the purpose of improving continuously. Artificial Intelligence has also a deep connection with the Neural Networks field. AI can be both a friend and an enemy to Critical Infrastructures and Space Critical Infrastructures, the assets that are essential for the functioning of a society and the economy. It can either help you predict when terrorists or other threats will strike a target or AI itself may turn against our systems. One of EU’s major objectives is to decrease the vulnerabilities of critical infrastructures and increase their resilience, thus, this paper investigates the ways in which the protection of Space Critical Infrastructures could be enhanced by the use of Artificial Intelligence.