While the Internet-of-Things (IoT) infrastructure is rapidly growing, the performance and correctness of such systems becomes more and more critical. Together with flexibility and interoperability, trustworthiness related aspects, including security, privacy, resilience and robustness, are challenging goals faced by the next generation of IoT systems. In this chapter, we propose approaches for IoT tailored access control mechanisms that ensure data and services protection against unauthorized use, with the aim of improving IoT system trustworthiness and lowering the risks of massive-scale IoT-driven cyber-attacks or incidents.