The paper deals with problems of water infrastructure management in the conditions of growing physical danger and cyber-threats. Countries with the largest water potential in the world which would be able to replace the markets of oil and gas by water-intensive technologies and require significant infrastructure projects in the future are identified. The author of study derived and described in the paper the pattern of “water problem globality principle” in the regional development. The emphasis is placed on the existence of the physical, cybernetic and human risk factors in water infrastructure management. It is suggested to take the American system of management of water infrastructure security as a reference.