Objective:

Exploring the clinical efficacy of autologous platelet-rich plasma (PRP), which has become a new approach to treat surgical wounds, especially in the treatment of osteoarthritis and refractory wounds.

Method:

PRP is derived from the centrifugation of autologous blood and plays an essential role in tissue repairing process. It contains a variety of growth factors that can stimulate cell proliferation and differentiation and facilitate healing of soft tissue, joints and wounds. Applying PRP in surgical practice can greatly reduce bleeding and enhance soft tissue healing and bone regeneration. We applied PRP extraction in the treatment of osteoarthritis and refractory wound patients.

Results:

(1) Osteoarthritis: 110 knee osteoarthritis patients with 220 affected knees, 10 cases of 20 joints were relieved after first PRP injection, 50 cases of 100 joints were relieved after the second injection, 44 cases of 88 joints were relieved after 3 times of injection, only 6 cases of 12 joints receives no significant effect. The effective rate of this group is 94.5%.

Conclusion: Intracavitary injection of PRP in the knee joint can effectively treat knee osteoarthritis and obtain favorable results in the short term, particularly in the treatment of patients with lower age or mild knee joint degeneration.

(2) Refractory wound: 18 cases, 12 cases of a traumatic wound, 2 cases of pressure ulcers, 1 cases of venous ulcer, 2 cases of diabetic ulcer foot, 1 case of chronic osteomyelitis, all healed.

Conclusion: PRP has obvious therapeutic effects on soft tissue wound reparation, without side effects, and painless. It can inhibit the growth of bacteria in the wound area, and effectively facilitate the repairing of soft tissue defect and the healing of bone and tendon wound. It is a safe, minimally invasive and efficacious treatment.