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Background:
A kind of biopolymer microsphere based on halloysite nanotubes (HNTs) were loaded insulin for oral administration.
Objective:
In order to increase the bioavailability of insulin and overcome the gastrointestinal (GI) enzymatic degradation for delivery of insulin by oral administrationfor the treatment of diabetes.
Methods:
Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscopy (SEM), swelling property, release profiles, biocompatibility, acute oral toxicity and HE staining were tested.
Results:
INS could be successfully loaded on the HNTs, and the biopolymer microspheres exhibited an egg-box structure which contributed INS loading. Besides, composite microspheres with smart a pH responsive act as an insulin delivery system.
Conclusion:
The intelligent pH response system for oral delivery of insulin was a relatively safe and effective drug delivery system, and it has great potential to achieve insulin oral administration for the treatment of diabetes.