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pH Response and Biosafety of Composite Microspheres with Halloysite Nanotubes Loaded Insulin
Yongtao Yang, Fan Leng, Yun Chen, Yinping Li, Fang Liu, Zan Tong, Shirley Shen, Weiqun Tian
113 - 121
10.3233/BHR190030
Research Article
Biomedical and Health Research
Volume 79: Stem Cells and Regenerative Medicine
Abstract

Background:

A kind of biopolymer microsphere based on halloysite nanotubes (HNTs) were loaded insulin for oral administration.

Objective:

In order to increase the bioavailability of insulin and overcome the gastrointestinal (GI) enzymatic degradation for delivery of insulin by oral administrationfor the treatment of diabetes.

Methods:

Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscopy (SEM), swelling property, release profiles, biocompatibility, acute oral toxicity and HE staining were tested.

Results:

INS could be successfully loaded on the HNTs, and the biopolymer microspheres exhibited an egg-box structure which contributed INS loading. Besides, composite microspheres with smart a pH responsive act as an insulin delivery system.

Conclusion:

The intelligent pH response system for oral delivery of insulin was a relatively safe and effective drug delivery system, and it has great potential to achieve insulin oral administration for the treatment of diabetes.

$35.00 / €27.50 / £22.00
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