Gene editing is to insert, delete, modify or replace target gene into the genome of a living organism. The most common technique is to import a recombinant vector (such as a plasmid or lentivirus containing a target-gene) in order to get one new hereditary mark to change the target cells’ function and characteristics or differentiate target cells into a particular direction. Mesenchymal stem cell (MSC) is a kind of pluripotent stem cells with high ability of self-proliferation and can be differentiated into osteoblasts, chondrocytes, adipocytes, etc. Because of its potential of multidirectional differentiation, with the development of regenerative medicine, MSC has become one of the ideal seeding cells for tissue engineering and cell therapy. Researches have shown that gene editing technique regulates the differentiation of MSCs. In this review, we mainly discuss the latest research progress in gene editing techniques applied in mesenchymal stem cells’ differentiation.
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
Tel.: +1 703 830 6300
Fax: +1 703 830 2300 email@example.com
(Corporate matters and books only) IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer Service
West Point Commons
Lansdale PA 19446
Tel.: +1 866 855 8967
Fax: +1 215 660 5042 firstname.lastname@example.org