In this paper we elaborate a preliminary framework to fill this gap and describe the potential contributions of HFE to improve digital health interventions, at the macro, meso and micro level of a health system. Researchers present a practical approach, integrated with some limited reflections on methodological aspects, recently covered in a position paper [8], while previously in conference series and handbooks. This paper presents a HFES perspective on digital health – from the macro, meso and micro level to improve patient safety and delivery of quality care. Experts in HFE can play a key role in creating evidence for an ethical and effective design of digital health intervention and providing support to their implementation and evaluation at the macro, meso and micro level. This framework may help to integrate HFE at the different levels of the system and following the tracks of organization, technology and human factors.