Information value chain theory provides a straightforward approach to information system evaluation and design. It first separates the different benefits and costs that might be associated with the use of a given information technology at different stages along a value chain stretching from user interaction to real world outcome. Next, using classical decision theoretic measures such as probabilities and utilities, the resulting value chain can be used to create a profile for a particular technology or technology bundle. Value chain analysis helps focus on the reasons for system implementation success or failure. It also assists in making comparative assessments amongst different solutions, to understand which might be best suited for different clinical contexts.