The last four decades witnessed a huge progress in digitizing health information, representing an unmatched opportunity for utilizing health analytics in improving the quality of healthcare and reducing its costs. To learn more about different challenges facing the successful utilization of health analytics, a careful review of literature was conducted, and a qualitative analysis was used to explore and classify these challenges. Three main categories of challenges were identified. 1) Technological challenges; hardware, software, and data content, 2) Human challenges; knowledge, experiences, beliefs and attitudes, and end user behaviors, and 3) Organizational challenges; managerial, financial, and legal barriers to optimal utilization of health analytics. The non-technological problems seem to be harder to solve as well as more time consuming, including the existence of a specific business need and a clear vision to guide the project. In addition, health analytics should always be built with the end users in mind.