This lecture is dealing with new, future forms of collaboration and with its (hopefully existing) extended synergies, which may now will come in our era of digitization. Entities in this collaboration are we, the human beings, and other living entities such as animals with ‘natural intelligence’ as well as non-living entities, in particular functionally comprehensive machines, with ‘artificial intelligence’. Based on lessons learned during the last years, among others in a task force on synergy and intelligence (SYnENCE) of the Braunschweig Scientific Society, five consequences for future health care with respect to this collaboration are put for discussion: (1) functional comprehensive ‘intelligent’ machines should be regarded as entities, not as modalities, (2) such machines have to become users of information systems in health, in addition to human entities, appropriate (3) legal and (4) ethical frameworks have to be developed, (5) extended collaboration in medicine and health care needs to be evaluated in accordance with good scientific practice. The statements of Karl Jaspers, made in 1946 on medicine and on technology, may help us to find a good way.