Sensor technologies and their integration with advanced software applications are fostering a new era of safety and healthiness. Factories of the future can benefit from the integration of ambient and wearable sensors in the workplace, as the worker him/herself can provide a reliable real-time profile of the conditions and adaptation to the work environment and demands. The information collected by the network of sensors can be aggregated and displayed in a dashboard in a simple but effective way, enabling health professionals to revise and follow-up massive streams of data. These huge amounts of data can be turned into meaningful information with the support of intelligent algorithms capable of processing data and detecting abnormalities. Our vision of the absolute healthy and safe factory of the future introduces the Medical Response Center (MRC), a unit capable of monitoring the factory from a computer. One of the main weaknesses of current factories is the lack of completeness in the information related to worker health, which subsequently is one of the major challenges industrial environments. Isolated health data are not enough to obtain an accident-free and safety factory. Time to time monitoring should be turned into a continuous health vigilance. Our view of the factory is as source of large amounts of data (for example, employee monitoring; environmental monitoring; medical decision support system; management protocols systems; treatment and adherence to therapy systems). This chapter aims at proposing an architecture which allows the exchange of information and connection between several intelligent services and devices, where all generated data are stored, selected, treated, etc. The first part of the chapter is devoted to explain in general terms the course followed by the information in order to achieve continuous worker vigilance. Secondly, and as a main block, the decision support system architecture is detailed. This architecture consists of a choreographer core that receives information of several services and devices. This proposal is thereafter linked to an ergonomics case, that is, with ergonomics from the point of view of a physical response to a specific need of the worker. Our case elaborates on detecting that a worker has visited the medical office for a defined number of times in the last months as an indicative of continuous discomfort. The medical study in detail can lead to a postural change or a reorganization of your workplace (for example due to shoulder problems); which is an improvement in the work place and ergonomics. This case is illustrative as it is not a direct consequence of a value collected through health wearable sensors, but data collected in the MRC, in which the review of health data is essential to rule out other diseases and generate an adequate diagnosis.