The Empirical ConWep, Multi-Material Arbitrary-Language-Euler (MM-ALE) and Smooth-Particle-Hydrodynamics (SPH) are most widely used methods for numerical evaluation of blast-loaded structures. They differ in the possibilities they offer, their computational efficiency as well as the required scientific and numerical knowledge for their proper and effective usage. They have their own advantages and disadvantages depending also on the structural geometry and its relative position with regard to the blast wave source location. In this paper, the results comparison of a detailed numerical examination using the ConWep, MM-ALE, and SPH methods is presented. The simulation tests were performed using armour steel plates in LS-DYNA. The comparison results showed that the ConWep and SPH methods offer better results and efficiency and require a lower level of user experience compared to the MM-ALE method. The results of this paper are important in the decision making process, when selecting an appropriate method for blast response analyses of structures.