Sickle cell disease is a major public health problem in Senegal. It is an inherited disease that affects about 300,000 births worldwide each year. There are 70 million people affected worldwide, 80% of whom live in sub-Saharan Africa. In Senegal, 1 in 10 people carries the sickle cell disease gene. This disease requires follow-up from birth and for life. The patient care requires the integration and the analysis of biological, clinical, social, economic data., etc. In this paper, we propose a health information system for data management of the blood sampling from the newborn at the maternity wards and the disease screening at the Center for Research and Ambulatory Care of the Sickle Cell Disease (CERPAD).