Dr. Klaus Schwab, Founder and Executive Chairman of the World Economic Forum, postulates that we are in a Fourth Industrial Revolution that will be characterized by “a fusion of technologies…blurring lines between the physical, digital, and biological spheres” [1]. These commercial developments will impose social stresses, increase pressures for migration, and affect military areas such as command, control, communications, computing (C4), intelligence, surveillance, and reconnaissance (ISR). It will also lead to proliferation of “small, smart, and cheap” weapons that can increase the cost of expeditionary operations. While most of these developments are outside government control, they must nevertheless be understood by national security decision-makers and incorporated into planning. The paper explores opportunities and risks for Southeast Europe (SEE).