The present work deals with the main challenges and constraints inherent to the factories of the future (FoF), especially those related to resilience and hacking risks. After a brief historical review of the industry evolution through the ages, the authors focus on the technical and technological specificities of the so-called industry 4.0 and propose an original Security Simulator Platform for cyber-attacks evaluation in real life industrial production systems, based on the CPS concept (Cyber-Physical System). For this, a graphic architecture is proposed to study the different flows and exchanges between the physical part (manufacturing system) and its ecosystem (Customers, suppliers, stocks, etc.). Then, a numerical model under Witness software, is built, in order to analyze the behavior of the global system (Soft and Hardware) in the event of possible integrity breach and cyber-attacks. The developed model is based on a set of mathematical algorithms and numerical techniques to ensure an intelligent cyber control of the resilience the industrial system.