Environment friendly production is an emerging trend in industrial production. Enhancing environmental protection and ensuring company's profitability have gained great attention from any manufacturers. The use of Overall Equipment Effectiveness (OEE) to reflect efficiency of production has been widely applied in the manufacturing process. However, the full advantage of OEE as a measure to simultaneously facilitate reduction of carbon dioxide (CO₂) emissions and to sustain the existing profitability has not been utilized. This study aimed to investigate the use of OEE to improve the manufacturing process of corrugated paper production using two indicators including CO₂ emission and profitability. The research showed a model of measuring OEE, CO₂ emission and Profitability. The obtained results indicated that impact 1 and impact 2 could maintain the same profitability (9%) but OEE and CFP from impact 1 (37% and 26%, respectively) were higher than those from impact 2 (12% and 8%, respectively). The overall results revealed that when improving OEE, CO₂ emission per product (1m²) could be significantly reduced while profitability could be increased in the production of corrugated paper.