Data explosion and the tremendous growth in the amount of data that is being generated from various IT services increases an enormous demand for smartly analysing the generated data (structured and unstructured). Since Big data constitutes three V's (Volume, Velocity, and Variety), Machine learning is the best solution for exploiting the information hidden in Big data. With far less dependence on manual direction, it provides various methods and techniques to mine useful information from big and disparate data sources. For better and precise results, Machine learning techniques require a huge volume of data and high computation power. Therefore, to get cost-effective infrastructure Cloud computing is the best option. This chapter is aiming to motivate the beginners, professionals and data analysts to adopt the combination of all these technologies. The product outcomes would help decision makers belonging to different domains in decision-making process. Further, this chapter is exploring state of the art technologies and its benefits on a social/commercial organization.