The aim of this article is to present the key achievements in the implementation of the Integrated Telemedicine and e-Health program in Albania, supported by US government agencies, implemented by International Virtual e-Hospital Foundation in partnership with Albanian Ministry of Health. The IBOT (initiate–build–operate–transfer") strategy was used by IVeH to establish an effective telemedicine system in Albania that includes the National Telemedicine Center and 5 university, 11 regional and 3 municipal hospital telemedicine centers throughout the country. This nationwide telemedicine network has several active clinical programs, virtual educational programs, and an electronic library. Experiences in Albania show that the application of sustainable and low-cost telemedicine programs not only improves access to health care but can overcome the existing unmet needs, thus significantly improving health services throughout the country. The IVeH telemedicine network in Albania provides a solid experience that can be expanded in countries with limited financial and technical capacities, as a model to build on to improve access to quality of health care in professional and timely manner.