Within the objectives of the Digital Agenda for Europe, the European Commission has co-funded flagship projects, in order to pilot test and evaluate the deployment of large scale telemedicine projects (United4Health and Renewing Health) in every day e-health and e-care services practice. The Region of Central Greece participated in these large scale EU co-funded projects in order to permit a comprehensive approach in the assessment methodology within the national health care services, providing also sufficient to draw valid conclusions on the effectiveness of the installed telemedicine services. Future telehealth services in Central Greece will be upgraded via Internet of Things technology, implementing large scale IoT e-health and e-care services via the ACTIVAGE EU co-funded project.