A recent trend in healthcare is to motivate patients to self-manage their health conditions in home-based settings. Medication adherence is an important aspect in disease self-management since sub-optimal medication adherence by the patient can lead to serious healthcare costs and discomfort for the patient. In order to alleviate the limitations of self-reported medication adherence, we can use ambient assistive living (AAL) technologies in smart environments. Activity recognition services allow to retrieve self-management information related to medication adherence in a less intrusive way. By remotely monitor compliance with medication adherence, self-management program's interventions can be tailored and adapted based on the observed patient's behaviour. To address this challenge, we present an AAL framework that monitor activities related to medication adherence.