Synchrotron radiation (SR)-based techniques are increasingly benefiting the chemical analysis of ancient and artistic materials. The unique properties of these techniques (e.g. non-invasiveness, variety and complementarity of probing methods, broad spectral range, high brightness and therefore small probe size and high beam flux even in monochromatic mode and imaging capabilities) are particularly well suited in the context of the technical constraints associated to the study of these materials (preciousness, complexity, heterogeneity). This article reviews a selection of methodological developments aiming at a further integration of SR-based techniques into the full tool-kit available in the field of analytical chemistry for Cultural Heritage (CH). In addition to these developments, a stronger exchange between the two communities (through schools, fields conferences, …) strongly participate in strengthening the link between SR and CH. Finally, it is worth noting that the technology transfer from SR facilities to CH labs and ultimately up to portable equipment is another example of this cross-fertilisation.