The use of telemedicine across national boundaries requires an understanding of the legal and regulatory challenges that we face in addressing application of telemedicine in disaster response and other humanitarian activities. This chapter focuses on multiple legal and regulatory considerations related to providing telemedicine services across international borders. While clinical standards of care across medical and surgical disciplines are fairly well-defined and generally accepted across the globe, there are various legal and regulatory laws, policies and procedures which limit physicians from openly engaging in the practice of medicine across international borders.