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Treponemes include the agents of syphilis, yaws, and other diseases, but as a group are fastidious organisms that often can only be grown in animals. This has hampered molecular analysis, but much progress is being made since genome sequences for these bacteria have been completed. The current state of the art involves comparative genomics, microarrays, whole genome clone sets, and other tools to unravel the biology of these pathogens.
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