Nowadays companies are pushed to offer solutions with new functionalities, higher performances, lower environmental impact, lower cost, and high usability for final users. In this context, the concept of Product-Service System (PSS) represents a valid way from manufacturing firms to evolve their market proposition, reduce impacts of their processes, and satisfy the customers' needs. However, the design of PSS is still difficult, due to the lack of structured methodologies and evidences of the benefits connected with their adoption. The research adopts a systematic QFD-based methodology and demonstrates its validity to develop high sustainability PSS solutions. The case study focuses on the definition of a new PSS for green roofs: two groups of students, using respectively traditional methods and the proposed QFD-based methodology, were involved. The two PSSs conceived were evaluated in terms of outputs supporting the design phases and sustainability impacts. The case study results demonstrated how the adoption of a systematic method allows developing more business-oriented and more sustainable PSS in respect to traditional methods.