Since electronic healthcare records are widely implemented in the hospitals, the explosion of the clinical data brings great opportunities to secondary use. Clinical data repository (CDR) plays an important role in clinical data using, including healthcare service, research and management. With evolving of clinical knowledge, it is a challenge for CDR to meet more and more requirements with adaptability and flexibility. In order to overcome this challenge, this paper proposed a solution that implemented a CDR with openEHR approach from data model to implementation. This study modelled archetypes according actual CDR requirements and implemented a CDR system in a tertiary hospital. Furthermore, this study developed data applications to facilitate healthcare service and research based on the CDR. The results of CDR system and data application demonstrate that openEHR approach could meet the continually evolving need of systems.