The pHealth 2016 Conference is the 13th in a series of scientific events bringing together expertise from medical, technological, political, administrative, legal and social domains. pHealth 2016 opens a new chapter in the success story of the series of international conferences on wearable or implantable micro, nano and biotechnologies for personalized health. Starting in 2003 with personal health management systems, pHealth has continuously extended its scope evolving to a truly interdisciplinary event by covering technological and biomedical facilities, legal, ethical, social, and organizational requirements and impacts as well as necessary basic research for enabling the future proof care paradigms. Thereby, pHealth increasingly combines medical devices and eHealth based services with public health, prevention, social and elderly care, wellness and personal fitness to establish participatory, predictive, personalized, preventive, and effective care settings. Smart mobile systems, eHealth and telemedicine have become important enablers for ubiquitous pervasive health as the next generation health services. Social media and gamification has added even further knowledge to pHealth both as a business domain and as a community safety-net.

The pHealth2016 conference aims to further emphasise on the integration of biology and medical data, systems and information using mobile technologies through the development of micro-nano-bio smart systems for pHealth emphasizing on personalized health, virtual care, precision medicine, big bio-data management and analytics as well as security, privacy and safety issues.

We welcome you to the city of Heraklion on the beautiful island of Crete for the pHealth 2016 conference to share experiences and results, and to open up for the future!

Following a long-term tradition, pHealth 2016 is supported by the European Federation for Medical Informatics (EFMI)but also the HL7 International. The pHealth 2016 presentations are complemented by demonstrations of practical artifacts and solutions as well as by a students' poster competition. This proceedings volume covers 2 keynotes and 2 specially invited talks, but also 21 oral presentations selected from more than 45 submissions to the pHealth 2015 conference, and 10 poster presentations. All submissions have been carefully and critically reviewed by at least two independent experts from other than the authors' home countries, and additionally by at least one member of the Scientific Program Committee. The performed highly selective review process resulted in a full papers rejection rate of more than 30%, thereby guaranteeing a high scientific level of the pHealth 2016 published papers. The editors are indebted to the acknowledged and highly experienced reviewers for having essentially contributed to the quality of the conference and the book at hand. Both the pHealth 2016 Conference and the publication of the pHealth 2016 proceedings at IOS Press would not have been possible without the supporters and sponsors Health Level 7 International (HL7 International), and European Federation for Medical Informatics (EFMI). The editors are also grateful to the dedicated efforts of the Local Organizing Committee members and their supporters for carefully and smoothly preparing and operating the conference. They especially thank all team members from IMBB-FORTH and CERTH/INAB-AUTH Lab of Computing & Medical Informatics, for their dedication to the event.

Nicos Maglaveras, Electra Gizeli (Editors)