An emerging alternative to the problem of knowledge looks towards information as playing a critical role in support of an externalist epistemology, a new theory of knowledge that need not rely upon the traditional but problematic tenets of belief and justification. In support of this information-theoretic epistemology, the relationship between information and knowledge both within philosophical and information technology scholarship has been viewed as an asymmetric one. This relationship is captured by the commonsense view that objective semantic information is prior to and encapsulated by knowledge [1]. This paper develops an argument that challenges this asymmetric assumption. Drawing on the ideas of Gareth Evans [6] and Timothy Williamson [5] we shall argue that (at least in some cases) a coextensive relationship must exist between information and knowledge. We conclude with the view that this relationship throws up problems similar to those discussed by Quine [15] in relation to confirmation holism.